Combination GAG Therapy
iAluRil is a medical device manufactured by Aspire Pharma, for the treatment of cases where the loss of components of the bladder lining causes chronic inflammation and infection.
iAluRil can be used to treat:
- Interstitial cystitis/painful bladder syndrome;
- Chemical cystitis – damage to the bladder lining caused by chemotherapy;
- Radiotherapy-induced cystitis – damage to the bladder lining caused by radiation to the pelvis;
- Recurrent urinary tract infections.
iAluRil works directly on the bladder lining to form a protective barrier between the bladder lining, and the irritant compounds found in urine.
iAluRil is a CE Marked product and is available in the following presentation:
- Prefilled syringe containing 50ml solution of high concentration Sodium Hyaluronate (1.6% w/v – 800mg / 50ml) and Sodium Chondroitin Sulfate (2% w/v – 1g / 50ml) with a luer-lock adaptor
How does iAluRil work?
In a healthy bladder there is a natural barrier that protects the bladder lining from the urine. This barrier is called the glycosaminoglycan (GAG) layer. If this barrier is damaged, urine comes into direct contact with the tissues of the bladder lining and over time can cause damage to these tissues. This damage can lead to a range of problems that cause symptoms, such as pain, urgency (the need to go to the toilet immediately) and frequency (the need to go to the toilet more often). iAluRil contains two of the natural GAGs that form this barrier; hyaluronic acid (HA) and chondroitin sulfate (CS). By administering iAluRil directly into the bladder, these GAGs help to repair the damage to the GAG layer and restore the bladder’s protective coating, relieving these symptoms.
How is iAluRil administered?
iAluRil is administered directly into the bladder using a prefilled syringe that is passed through the urethra (the passage through which urine comes out when you go to the toilet) into the bladder. Before administering iAluRil, you will need to urinate and then the bladder can be emptied of all traces of urine by inserting a catheter and waiting for all of the urine to leave the bladder. When the liquid has been passed into your bladder it should be held there for at least half an hour. Once it can be held no more, the bladder can be emptied by urinating as normal.
This is a relatively painless and routine procedure, which may initially be carried out by a doctor or a nurse, however, many patients can be taught to do this themselves as it is very simple. If this is something that you feel you would prefer to do, then do discuss this with your doctor or nurse and they will be able to offer more advice.
How long will my treatment last?
iAluRil treatment begins with a course of instillations given once a week for the first month. The instillations will then be given once every two weeks for the second month followed by once every month until the symptoms settle down. Once the symptoms have improved, the interval between instillations can be increased slowly until you are happy that the regular doses are enough to keep symptoms under control. If the symptoms reoccur, the initial course of instillations can be repeated in order to settle the symptoms down again.
Will I get any side effects?
iAluRil is contraindicated in patients with known hypersensitivity to the active substances or any of the excipients. If you do experience any side effects discuss them with your nurse or doctor and between you a decision can be made whether to continue with or stop treatment.
For more information download our brochure by clicking here.